KMID : 0363520010140020231
|
|
Journal of Oriental Medical Surgery, Ophthalmology & Otolaryngology 2001 Volume.14 No. 2 p.231 ~ p.252
|
|
Studies on Inhibitory Effect of Immediate-Type Allergic Reaction of Mahwang -Shin-Gung - San
|
|
ÃÖÁ¤Çö/Choi JH
ȲÃ濬/±è³²±Ç/¹Ú¹Îö/±èÁø¸¸/¹®»óµ·/Whang VH/Kim NK/Park MC/Kim JM/Moon SD
|
|
Abstract
|
|
|
Mahwang-Shin-Gung-San has been found inhibiting the mast cell-mediated anaphylactic reaction. This report describes an inhibitory effect of Mahwang-Shin-Gung-San (MSGS) on the immediate-type cutaneous allergic reactions. MSGS has concentration -dependendy inhibited the ear swelling response induced by compound 48/80 in mouse by intradermal injection. The mast cells in mouse ear tissue undergone ear-swelling response by compound 48/80 were stained by alcian blue/nuclear fast red. MSGS significantly inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. MSGS concentration-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC). by compound 48/80. We also studied the effect of MSGS on mast cell-dependent passive cutaneous anaphylaxis (PCA) activated by dinitrophenyl IgE antibody. MSGS showed potent inhibition of PCA by oral administration. These results indicate that MSGS inhibits
immediate-type allergic reactions by inhibition of mast cell degranulation in ulvo and in uitro.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|